be2010R3 using B2D - Target iSCSI Drive on file server

I am attempting to setup a B2D backup rotation, I have everything running except backing up an iSCSI drive mapped to my file server.

The Tape backups backup the iSCSI drive fine.

The backup server maps the B2D Folder to an iSCSI drive, and attempts to backup another iSCSI drive on another server, but cannot find the folder specified.

All other files and folders on servers not housing an iSCSI drive backup normally to the b2d drive.

I can make the backup and see the folders in question on the backup interface.

The iSCSI drives are shared out from a Dell SAN MD3220i

Backup Server: BE 2010 R3, Server 2008 R2

File Server: Server 2008 R2

Error Message: E00084AF